This 2016 ECSEL Multi Annual Strategic Research and Innovation Agenda (MASRIA), on behalf of the ECSEL Private Members Board (PMB), serves as input/recommendation for the 2015 6 Multi-Annual Strategic Plan (MASP) of the ECSEL Joint Undertaking. This MASRIA describes the Vision, Mission and Strategy of the ECSEL JU as well as the strategic research and innovation activities (in its Parts A and B) to be undertaken through the ECSEL-Calls of coming years in order to enable the ECSEL JU to fulfil its objectives.